With 6" wheels you will be running wheel arch extensions, so it's not really a problem. The arch extensions will easily fit to a slightly modified wing as the alteration is only very localised.
If running without arch extensions, once the wheel arch flange has been altered it usually damages the paint, so it is necessary to re-finish the paintwork.
If a 4.5" wheel is causing the tyre to foul on the wing it is likely that one of two things is true. Either the caster is too great and adjustable tie bars might sort the problem, or the suspension is too low due to worn suspension cones or split knuckles in the lower ball end of the trumpet (or both).
It is a common problem and not difficult to resolve with a hammer, a pair of big pliars and an angle grinder!