Bit hard to reduce the harmonics - they are largely produced from the 'bang' that occurs above the piston and the size of it. So at the risk of sounding like a wise guy, the way to reduce the harmonic is to reduce the Horse Power.
However, what we can do is to control the effects of the harmonics and move the resonant points. In part it is done with the Harmonic Damper fitted to the Nose of the Crank, ensure that it suitably tuned for the engine (not an easy task). Something else that is often done is to lighten the bottom end, which if done right, will move (hopefully!) the harmonic resonant points outside of the engines normal and maximum rev range.